Details

Autor(en) / Beteiligte

• Pereira, Maria Liliane Luciano
• Costa, Mac Dionys Rodrigues da
• Viana, Glautemberg de Almeida
• Magalhães, Emanuel Paula
• Duque, Bruna Ribeiro
• Silva, Mateus Edson da
• Teixeira, Izabell Maria Martins
• Alves, Renata de Sousa
• Menezes, Ramon Róseo Paula Pessoa Bezerra de
• Martins, Alice Maria Costa
• Queiroz, Maria Goretti Rodrigues de
• Sampaio, Tiago Lima

Titel

Correlation of Apolipoprotein a-i with Renal Function in Diabetic Patients

Ist Teil von

• Brazilian Archives of Biology and Technology, 2024, Vol.67

Ort / Verlag

Instituto de Tecnologia do Paraná - Tecpar

Erscheinungsjahr

2024

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract Diabetes mellitus (DM) is a major cause of chronic kidney disease (CKD) and changes in lipoprotein. Literature data suggest that cholesterol associated with high-density lipoprotein (HDLc) plays a protective role against albuminuria and diabetic nephropathy. These factors are related with changes in serum apolipoproteins such Apo A-I. This work aims to evaluate the correlation of apolipoprotein A-I with renal function in diabetic outpatients. Samples were collected from 281 outpatients for analyses of glycated hemoglobin (HbA1c), serum creatinine (SCr), urea (BUN), cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDLc) and estimation of glomerular filtration rate (eGFR). Urinary samples were obtained to assess urine albumin creatinine ratio (UACR). Triglyceride-glucose index (TyG) was calculated to estimate insulin resistance. The mean age was 61,5 ± 16,4 years. Most patients were female, Afro-Mestizo and over 50 years of age. Pearson's revealed negative correlation of creatinine with HDLc and Apo A-I. There was a correlation of eGFR with HbA1c, TG and HDLc. TyG presented a negative correlation with Apo A-I and HDLc. The highest quartiles of UACR presented the highest TyG and the lowest Apo A-I. In conclusion, Apo A-I indicated an association with insulin resistance and changes in renal function parameters, especially as a factor associated with the onset of albuminuria, with a better predictive potential than the HDLc.