Details

Autor(en) / Beteiligte

• Singh, Brij Mohan Kumar
• Mathew, Mary

Titel

Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis

Ist Teil von

• Brazilian Archives of Biology and Technology, 2022-01, Vol.65

Ort / Verlag

Instituto de Tecnologia do Paraná - Tecpar

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies. The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.