Details

Autor(en) / Beteiligte

• Marques, Julia Hatagami
• Talib, Leda Leme
• Hortêncio, Lucas
• Andrade, Julio Cesar
• Alves, Tania Maria
• Serpa, Mauricio Henriques
• Yamamoto, Guilherme Lopes
• van de Bilt, Martinus Theodorus
• Rössler, Wulf
• Gattaz, Wagner Farid
• Loch, Alexandre Andrade

Titel

A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis

Ist Teil von

• Revista brasileira de psiquiatria, 2023, Vol.45 (3), p.268-273

Ort / Verlag

Associação Brasileira de Psiquiatria

Erscheinungsjahr

2023

Link zum Volltext

Beschreibungen/Notizen

• Objectives: To test the association of 45 single nucleotide polymorphisms (SNPs) with transition to psychiatric disorders in a cohort of individuals at ultrahigh risk (UHR) mental state for psychosis. Methods: Through general population screening, 88 non-help-seeking UHR subjects and 130 healthy control individuals were genotyped for 45 SNPs related to psychosis. They were followed for a mean of 2.5 years, and conversion to psychotic and to general psychiatric disorders was assessed. Genotype frequencies between controls, converters, and non-converters were analyzed. Results: There were no differences in sociodemographics between controls and UHR. Also, UHR converters and non-converters had no differences in their baseline symptoms scores. The dopamine receptor D2 gene (DRD2) SNP rs6277 was significantly more common among UHR who transitioned to psychosis (p < 0.001) and to UHR who transitioned to any psychiatric disorders (p = 0.001) when compared to UHR who did not transition. The rs6277 T allele was related to psychiatric morbidity in a dose-response fashion, being significantly more frequent in UHR converters than UHR non-converters and control subjects (p = 0.003). Conclusion: Our findings suggest that rs6277 could potentially constitute a genetic marker of transition to psychiatric disorders in subjects with at-risk mental states, warranting further investigation in larger samples.