Details

Autor(en) / Beteiligte

• Torres-Sánchez, Erandis D
• Pacheco-Moisés, Fermín P
• Macias-Islas, Miguel A
• Morales-Sánchez, Eddic W
• Ramírez-Ramírez, Viridiana
• Celis de la Rosa, Alfredo J
• Cid-Hernández, Margarita
• Sorto-Gómez, Tanya E
• Ortiz, Genaro G

Titel

Effect of fish and olive oil on mitochondrial ATPase activity and membrane fluidity in patients with relapsing-remitting multiple sclerosis treated with interferon beta 1-b

Ist Teil von

• Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral, 2018-01, Vol.35 (1), p.162-168

Ort / Verlag

Spain: Grupo Arán

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with increased oxidative stress (OS) and mitochondrial alterations. Fish oil consumption has neuroprotective, antioxidant and anti-inflammatory effects in patients with relapsing-recurrent MS (RR-MS). To evaluate changes in the hydrolytic activity of ATP synthase and mitochondrial membrane fluidity in patients with RR-MS who receive fish oil or olive oil as a dietary supplement. Clinical, controlled, randomized, double-blind trial. Patients consumed fish oil or olive oil for one year. The hydrolytic activity of ATPase and the fluidity of the mitochondrial membrane of platelets were quantified. In patients with RR-MS, a decrease in the fluidity of mitochondrial membranes and an increase in the hydrolytic activity of ATP synthase was observed in comparison with healthy controls. After 6 or 9 months of treatment with fish oil or olive oil, respectively, these values were normalized. The consumption of fish oil and olive oil increases the fluidity of the mitochondrial membranes and decreases the catabolic activity of ATP synthase in platelets from patients with RR-MS.