Details

Autor(en) / Beteiligte

• Monte, Zenaide S.
• Navarro, Daniela M. A. F.
• Aguiar, Júlio C. R. O. F.
• Nascimento, Jessica S.
• Scotti, Marcus T.
• Scotti, Luciana
• Barros, Renata P. C.
• Santos, Aline C. S.
• Pereira, Valéria R. A.
• Falcão, Emerson P. S.
• Melo, Sebastião J.

Titel

Pyrimidine Derivatives: QSAR Studies of Larvicidal Activity against Aedes aegypti

Ist Teil von

• Journal of the Brazilian Chemical Society, 2020-07, Vol.31 (7), p.1531-1540

Ort / Verlag

Sociedade Brasileira de Química

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The present study investigated the activity of pyrimidine derivatives against Aedes aegypti. Two compounds, 3c and 3d showed excellent larvicide activity. Additionally, quantitative structure-activity relationship (QSAR) models were built using multiple-linear regression and partial least squares with descriptors generated from Dragon and VolSurf+ software, respectively. The best model is obtained with multiple linear regression (MLR), leading to a robust model. Moreover, the QSAR model is validated by means of some internal validation techniques in order to check its reliability, quality and robustness for predicting the larvicidal activity against A. aegypti. The models confirmed that the three-dimensional structure of molecules, steric properties, hydrophobic polar surface area, log partition (logP) and a simple pattern of substituent groups as methyl, methoxy, and succinimide in the pyrimidine derivatives are responsible for the larvicidal activity of the pyrimidine derivatives. Even more, the activity decreases by an electron-withdrawing group in R1 and increases when it is replaced by an aromatic ring activator group. These findings will aid in further studies of new pyrimidine derivatives active against Aedes aegypti.