Details

Autor(en) / Beteiligte

• Coelho-de-Souza, Andrelina N.
• Rocha, Maria Valdenir A.P.
• Oliveira, Keciany A.
• Vasconcelos, Yuri A.G.
• Santos, Edgleyson C.
• Silva-Alves, Kerly Shamyra
• Diniz, Lúcio Ricardo L.
• Ferreira-da-Silva, Francisco Walber
• Oliveira, Ariclécio C.
• Ponte, Edson L.
• Evangelista, Janaína Serra-Azul M.
• Assreuy, Ana Maria S.
• Leal-Cardoso, José Henrique

Titel

Volatile oil of Croton zehntneri per oral sub-acute treatment offers small toxicity: perspective of therapeutic use

Ist Teil von

• Revista brasileira de farmacognosia, 2019-03, Vol.29 (2), p.228-233

Ort / Verlag

Cham: Elsevier Editora Ltda

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] Croton zehntneri Pax & K. Hoffm., Euphorbiaceae, or “canela-de-cunhé” is used in the Northeast Brazil to treat several diseases. Leaves and aerial parts of C. zehntneri are rich in volatile oil of high potential therapeutic. This study aimed to investigate volatile oil systemic toxicity after per oral treatment in rats. Volatile oil characterization (gas chromatography and mass spectrometry) showed 85.7% anethole and 4.8% estragole. Male Wistar rats (116–149g) were treated with volatile oil (250mg/kg p.o.) during ten weeks and evaluated for the following parameters: survival; food and water intake; body mass; absolute/relative organs weight; hemogram; plasma biochemical dosage; organs morphology. Volatile oil did not alter animal water and food consumption or the relative/absolute weight of most organs, but animals gained less weight. Volatile oil did not alter function biomarkers of pancreas, kidney, heart or liver, but increased plasma gamma-glutamyltranspeptidase (liver biomarker) and decreased uric acid (kidney biomarker). Although volatile oil had caused discrete morphological alterations in some organs, it did not induce architectural changes in these organs. In conclusion, the sub-acute per oral treatment with volatile oil no longer than ten weeks in rats offers small toxicity at doses below 250mg/kg.