Details

Autor(en) / Beteiligte

• Lima, Igara Oliveira
• Costa, Vivian Bruna Machado
• Matias, Wemerson Neves
• Costa, Danielly Albuquerque da
• Antas e Silva, Davi
• Agra, Maria de Fátima
• Souza, Maria de Fátima Vanderlei
• Lima, Edeltrudes de Oliveira
• Batista, Leônia Maria

Titel

Biological activity of Herissantia crispa (L.) Brizicky

Ist Teil von

• Revista brasileira de farmacognosia, 2009-03, Vol.19 (1b), p.249-254

Ort / Verlag

Sociedade Brasileira de Farmacognosia

Erscheinungsjahr

2009

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The crude methanol extract (EMeOH) of the aerial parts of Herissantia crispa (L.) Brizicky, plant riches in flavonoids and without pharmacological studies, was tested to value its activity under the behaviour parameters and to determine the lethal dose (LD50) in mice; antimicrobial and antiulcerogenic activities. The EMeOH (5,000 mg/kg, v.o. or 2,000 mg/kg i.p.) did not alter the behaviour parameters and there were not mice deaths. The extract inhibited the bacterial growth. The EMeOH (750 mg/kg) showed anti-diarroeal activity. The EMeOH (250, 500 and 750 mg/kg) decreased the gastric lesions induced by 0.3 M HCl/ethanol 60% in mice. In conclusion, the EMeOH presents anti-ulcerogenic activity;, however it is necessary to value the antiulcerogenic activity in more specific models and to study the action mechanism by which the vegetable sample protects the gastric mucosa.