Details

Autor(en) / Beteiligte

• Razzaq, Syed Naeem
• Khan, Islam Ullah
• Ashfaq, Muhammad
• Mariam, Irfana

Titel

Stability indicating HPLC method for simultaneous determination of moxifloxacin hydrochloride and ketorolac tromethamine in pharmaceutical formulations

Ist Teil von

• Química Nova, 2012, Vol.35 (6), p.1216-1221

Ort / Verlag

Sociedade Brasileira de Química

Erscheinungsjahr

2012

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• A simple, RP-HPLC method was established for determining moxifloxacin and ketorolac in pharmaceutical formulations. Moxifloxacin, ketorolac and their degradation products were separated using C8 column with methanol and phosphate buffer pH 3.0 (55:45 v/v) as the mobile phase. Detection was performed at 243 nm using a diode array detector. The method was validated using ICH guidelines and was linear in the range 20-140 µg mL-1 for both analytes. Good separation of both the analytes and their degradation products was achieved using this method. The developed method can be applied successfully for the determination of moxifloxacin and ketorolac.