Details

Autor(en) / Beteiligte

• Nguyen, Cao Nguyen
• Nguyen, Duc Toan
• Tran, Ha An
• Mac, Dinh Hung
• Nguyen, Thi Thu Tram
• Retailleau, Pascal
• Nguyen, Thanh Binh

Titel

Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones

Ist Teil von

• Organic & biomolecular chemistry, 2024-05, Vol.22 (19), p.3871-3875

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported. Generated in situ from the starting components by using dbu as a base catalyst, the Michael adducts underwent a smooth oxidative cyclization into 3,4,6-triaryl-2-pyranones upon heating with DABCO and sulfur in DMSO. Extension to malonate in place of phenylacetates led to 4,6-diaryl-2-pyranone-2-carboxylates. A cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.