Details

Autor(en) / Beteiligte

• Huang, Ding-Yong
• Liu, Hong-Shi
• Wang, En-Hua
• Peng, Mei
• Deng, Ting-Fei
• Gao, Ming
• Liu, Sheng
• Li, Qi-Ji
• Yang, Li-Shou
• Yang, Xiao-Sheng

Titel

KF-catalyzed direct thiomethylation of carboxylic acids with DMSO to access methyl thioesters

Ist Teil von

• Organic & biomolecular chemistry, 2024-02, Vol.22 (7), p.1453-1457

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• With dimethyl sulfoxide (DMSO) as the methylthio source, a KF-catalyzed strategy was employed for the direct thiomethylation of carboxylic acids with DMSO for the preparation of methyl thioesters. In this process, a wide range of methyl thioesters were obtained in moderate to excellent yields. This novel strategy features the first use of DMSO as a methylthiolating agent for the construction of methyl thioesters, transition metal-free conditions, inexpensive reagents, easy workup, broad substrate scope and sustainability. Additionally, this procedure can be readily scaled up to a gram scale. A transition metal-free, KF-catalyzed synthesis of methyl thioesters has been developed via the direct thiomethylation of carboxylic acids with DMSO.