Details

Autor(en) / Beteiligte

• Kang, Chen
• Li, Mingzhe
• Huang, Wenxiu
• Wang, Shoucai
• Peng, Mengyu
• Zhao, Longqiang
• Jiang, Guangbin
• Ji, Fanghua

Titel

Electrochemical -acylation and -α-ketoacylation of sulfoximines the selective decarboxylation and dehydration of α-ketoacids

Ist Teil von

• Green chemistry : an international journal and green chemistry resource : GC, 2023-10, Vol.25 (21), p.8838-8844

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Sulfoximines are commonly found in pharmaceuticals, agrochemicals and other biologically active compounds. However, limited reports exist for their selective functionalization via green and efficient protocols. Herein, we describe an electrochemical N -acylation and N -α-ketoacylation of sulfoximines via the selective decarboxylation and dehydration of α-ketoacids. These two reactions use electricity as a "traceless" oxidant and α-ketoacid as a selective "acyl" or "α-ketoacyl" source. A broad range of acylated- and α-ketoacylated sulfoximines were isolated in good to excellent yields (up to 88% and 96% yields). Moreover, these protocols have also been applied to late-stage derivatizations of fenofibrate and can be safely conducted on a gram scale. We describe an electrochemical N -acylation and N -α-ketoacylation of sulfoximines via the selective decarboxylation and dehydration of α-ketoacids using electricity as a "traceless" oxidant and α-ketoacid as a selective "acyl" or "α-ketoacyl" source.