Details

Autor(en) / Beteiligte

• Wang, Zheng-Lin
• Zhang, Yun-Hao
• Huang, Jun-Yu
• Zhou, Jian
• Yu, Ya-Qin
• Feng, Dexin
• Xu, Da-Zhen

Titel

Iron-catalyzed intramolecular C-H amination for the synthesis of N-H carbazoles and indoles

Ist Teil von

• Green chemistry : an international journal and green chemistry resource : GC, 2023-06, Vol.25 (11), p.4463-4468

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The development of aerobic oxidative C-H/N-H cross-coupling catalyzed by the first-row transition metals is attractive yet challenging. Here, the first iron-catalyzed intramolecular cross-dehydrogenative coupling for the synthesis of carbazoles and indoles using air as the oxidant is reported. The general and efficient protocol allows for C-N bond formation under green conditions with excellent functional group compatibility, delivering a wide range of N-H carbazoles and indoles in good yields. Impressively, all carbazoles are prepared from 2-cyclohexenyl aminoarenes with the loss of 6Hs via a C-H amination and aromatization process. Furthermore, it also works for C-O bond formation. An iron-catalyzed intramolecular dehydrogenative coupling for the synthesis of N-H carbazoles and indoles with excellent functional group tolerance using air as the terminal oxidant is reported.