Details

Autor(en) / Beteiligte

• Tan, Yongbo
• Huang, Huawen

Titel

Catalyst- and additive-free cascade radical addition/cyclization of -arylacrylamides with trifluoropyruvates

Ist Teil von

• Chemical communications (Cambridge, England), 2023-11, Vol.59 (9), p.13462-13465

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Herein, we introduce a photocatalyst- and additive-free method for the preparation of valuable 3,3-disubstituted oxindoles bearing trifluoromethyl alcohol moieties from readily available acrylamides and cheap trifluoropyruvates. The excited trifluoropyruvates under ultraviolet-light irradiation react efficiently with acrylamides delivering a variety of trifluoromethyl oxindoles with broad functional group tolerance and moderate to good yields. This protocol features mild reaction conditions, simple operation and ready scalability. Redox-neutral coupling and cyclization: A photocatalyst- and additive-free method for the preparation of valuable 3,3-disubstituted oxindoles bearing trifluoromethyl alcohol moieties with formal 100% atom economy.