Details

Autor(en) / Beteiligte

• Dacon, Nicholas J
• Wu, Nathan B
• Michel, Brian W

Titel

Red-shifted activity-based sensors for ethylene direct conjugation of fluorophore to metal-carbene

Ist Teil von

• RSC chemical biology, 2023-11, Vol.4 (11), p.871-878

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• A number of Activity-Based Sensors (ABS) for relatively unreactive small molecules, such as ethylene, necessitates a transition metal for reaction under ambient conditions. Olefin metathesis has emerged as one of the primary strategies to achieve ethylene detection, and other transition metals are used for similarly challenging-to-detect analytes. However, limited studies exist investigating how fluorophore-metal attachment impacts photophysical properties of such ABS. Two new probes were prepared with the chelating benzlidene Ru-ligand directly conjugated to a BODIPY fluorophore and the photophysical properties of the new conjugated ABS were evaluated. Direction conjugation of a BODIPY fluorophore with the chelating ruthenium ligand result in red-shifted ethylene probes Con-BEP-4 and Con-BEP-5 . Synthesis, photophysical properties, and live cell imaging studies are reported.