Details

Autor(en) / Beteiligte

• Hu, Yongzhi
• Hou, Huiqing
• Yu, Ling
• Zhou, Sunying
• Wu, Xianghua
• Sun, Weiming
• Ke, Fang

Titel

Electro-oxidative cyclization: access to quinazolinones KSO without transition metal catalyst and base

Ist Teil von

• RSC advances, 2021-09, Vol.11 (5), p.3165-31655

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• A K 2 S 2 O 8 -promoted oxidative tandem cyclization of primary alcohols with 2-aminobenzamides to synthesize quinazolinones was successfully achieved under undivided electrolytic conditions without a transition metal and base. The key feature of this protocol is the utilization of K 2 S 2 O 8 as an inexpensive and easy-to-handle radical surrogate that can effectively promote the reaction via a simple procedure, leading to the formation of nitrogen heterocycles via direct oxidative cyclization at room temperature in a one-pot procedure under constant current. Owing to the use of continuous-flow electrochemical setups, this green, mild and practical electrosynthesis features high efficiency and excellent functional group tolerance and is easy to scale up. A K 2 S 2 O 8 -promoted oxidative tandem cyclization of primary alcohols with 2-aminobenzamides to synthesize quinazolinones was successfully achieved under undivided electrolytic conditions without a transition metal and base.