Details

Autor(en) / Beteiligte

• Thiel, Andreas
• Sauer, Daniel F
• Markel, Ulrich
• Mertens, M. A. Stephanie
• Polen, Tino
• Schwaneberg, Ulrich
• Okuda, Jun

Titel

An artificial ruthenium-containing β-barrel protein for alkene-alkyne coupling reaction

Ist Teil von

• Organic & biomolecular chemistry, 2021-04, Vol.19 (13), p.2912-2916

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A modified Cp*Ru complex, equipped with a maleimide group, was covalently attached to a cysteine of an engineered variant of Ferric hydroxamate uptake protein component: A (FhuA). This synthetic metalloprotein catalyzed the intermolecular alkene-alkyne coupling of 3-butenol with 5-hexynenitrile. When compared with the protein-free Cp*Ru catalyst, the biohybrid catalyst produced the linear product with higher regioselectivity. An artificial metalloprotein harboring an [(η 5 -pentamethylcyclopentadienyl)ruthenium( ii )] catalyst for the alkene-alkyne coupling reaction was developed.