Details

Autor(en) / Beteiligte

• Cheng, Hanlong
• Wang, Xueyan
• Liu, Xuan
• Wang, Xin
• Wen, Hao
• Cheng, Yinkai
• Xie, Anjian
• Shen, Yuhua
• Tang, Rupei
• Zhu, Manzhou

Titel

An effective NIR laser/tumor-microenvironment co-responsive cancer theranostic nanoplatform with multi-modal imaging and therapies

Ist Teil von

• Nanoscale, 2021-06, Vol.13 (24), p.1816-1828

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Cancer is still a major threat to human health at present. Developing new types of integrated nanoplatforms for the accurate diagnosis and effective treatment of cancer is very significant. Herein, an intelligent dual-stage core-shell cancer theranostic nanoplatform (Fe 3+ @Au1Ag24@PbP) with NIR laser/tumor-microenvironment (TME) co-responsiveness and multi-modal imaging-therapy was successfully prepared, which was composed of the precisely structured oil-soluble Au1Ag24 nanoclusters (NCs) and Fe 3+ ions easily assembled within the oil and aqueous phases of the polyethylene glycol (PEG) block grafted polyketal (PK) copolymer (PK- b -PEG, PbP) vesicles, respectively. In this system, we were delighted to find that the prepared Au1Ag24 NCs possess multi-photoresponsive properties, endowing the nanoplatform with photoacoustic (PA)/photothermal (PT) imaging and synergetic photothermal therapy (PTT)/photodynamic therapy (PDT) for cancer under near-infrared (NIR) laser irradiation. On the other hand, Fe 3+ ions exhibit multi-TME response and regulation behaviors, including as catalysts for the decomposition of endogenous hydrogen peroxide (H 2 O 2 ) in the solid tumor to produce O 2 and as the oxidizing agent for the consumption of the intracellular GSH to avoid the reduction of the generated 1 O 2 ; therefore, the synchronously formed Fe 2+ ions from the redox of Fe 3+ with GSH could further react with H 2 O 2 to produce hydroxyl radical (&z.rad;OH), which induced ferroptosis-based cancer treatment. The PbP shell possesses TME/pH sensitivity for controlled drug release and passive targeting, causing a large increase in Au1Ag24/Fe 3+ accumulation within the weakly acidic tumor region and reducing the side effects on normal tissues. Both in vitro and in vivo experiments demonstrate that the Fe 3+ @Au1Ag24@PbP nanoplatform presented excellent PA/PT imaging-guided synergetic PTT/PDT/ferroptosis effects toward tumor cells and tumors. This integrating multi-responsive and multi-modal theranostic nanoplatform paves a new way for effective cancer therapy. An effective cancer therapeutic nanoplatform with multi-modal imaging and synergistic photothermal/photodynamic therapy/ferroptosis.