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A novel dual-site ICT/AIE fluorescent probe for detecting hypochlorite and polarity in living cells
Ist Teil von
New journal of chemistry, 2021-11, Vol.45 (45), p.2146-21414
Ort / Verlag
Cambridge: Royal Society of Chemistry
Erscheinungsjahr
2021
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
A novel dual-site fluorescent probe (
CTPA
) was rationally designed and synthesized for the detection of hypochlorite (ClO
−
) and polarity.
CTPA
displayed an excellent sensitivity (LOD = 11.9 nM) and selectivity as well as a rapid response within 30 s to ClO
−
. Besides, it is worth noting that the introduction of triphenylamine into the D-π-A structure is beneficial to monitor the fluctuation of polarity. It was found that
CTPA
could respond to polarity fluctuation
via
the two channels of fluorescence intensity and maximum emission wavelength. In addition,
CTPA
exhibited low toxicity and was successfully applied to detect the endogenous and exogenous ClO
−
in HeLa cells and HIN-3T3 cells and distinguish the two kinds of cells by ClO
−
and polarity. Furthermore, this work provides a promising strategy for the development of dual-site fluorescent probes aiming at the detection of biologically relevant analytes by the collocation of recognizing groups.
A novel dual-site fluorescent probe (
CTPA
) was rationally designed and synthesized for the detection of hypochlorite (ClO
−
) and polarity.