Details

Autor(en) / Beteiligte

• Luo, Zhenli
• Pan, Yixiao
• Yao, Zhen
• Yang, Ji
• Zhang, Xin
• Liu, Xintong
• Xu, Lijin
• Fan, Qing-Hua

Titel

BF·EtO as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant

Ist Teil von

• Green chemistry : an international journal and green chemistry resource : GC, 2021-07, Vol.23 (14), p.525-5211

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF 3 ·Et 2 O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug molecules and biologically relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atmosphere or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF 3 and hydride transfer from formic acid. A versatile metal- and base-free direct reductive amination of aldehydes with primary and secondary amines catalyzed by inexpensive BF 3 ·Et 2 O using formic acid as a reductant has been developed.