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Fucoidans from ameliorate renal interstitial fibrosis inhibition of the PI3K/Akt/NF-κB signaling pathway
Ist Teil von
Food & function, 2022-02, Vol.13 (3), p.1168-1179
Erscheinungsjahr
2022
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
The effects of
Cucumaria frondosa
polysaccharides (CFPs) on renal interstitial fibrosis by regulating the phosphatidylinositol-3-hydroxykinase/protein kinase-B/nuclear factor-κB (PI3K/AKT/NF-κB) signaling pathway were investigated
in vivo
and
in vitro
in this research. The common unilateral urethral obstruction (UUO) model was used to examine the renoprotective effect and its mechanism
in vivo
. Compared to the UUO group, CFP administration could ameliorate renal function, inhibit inflammation and fibrosis, and reduce the deposition of the extracellular matrix and epithelial-mesenchymal transition. Mechanistic results indicated that CFPs could inhibit the expression of the total protein of PI3K and the conversion of the AKT and NF-κB p65 phosphorylated proteins, thereby inhibiting the transduction of the PI3K/AKT/NF-κB pathway. In addition, CFP treatment could improve inflammation and fibrosis in HK-2 cells induced by TGF-β1, and its
in vitro
mechanism was also verified to inhibit the PI3K/Akt/NF-κB signaling pathway. Overall, these results showed that CFP could alleviate renal interstitial fibrosis related to the PI3K/AKT/NF-κB signaling pathway.
The effects of
Cucumaria frondosa
polysaccharides (CFP) on renal interstitial fibrosis by regulating the PI3K/AKT/NF-κB signaling pathway were investigated
in vivo
and
in vitro
in this research.
Sprache
–
Identifikatoren
ISSN: 2042-6496
eISSN: 2042-650X
DOI: 10.1039/d1fo03067a
Titel-ID: cdi_rsc_primary_d1fo03067a
Format
–
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