Details

Autor(en) / Beteiligte

• Wu, Han
• Zhou, Wen-Jing
• Liu, Lan
• Fan, Ze
• Tang, Hao
• Yu, Ru-Qin
• Jiang, Jian-Hui

Titel

mRNA imaging based on tripartite DNA probe mediated catalyzed hairpin assembly

Ist Teil von

• Chemical communications (Cambridge, England), 2020-08, Vol.56 (62), p.8782-8785

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Herein, we develop a novel tripartite DNA probe to transport phosphorothioated substrate hairpins and an aptamer for the intramolecular CHA circuit, which achieves detection of a low amount of specific mRNA in living cells and mice. Our study provides an improved strategy to promote in vivo fluorescence imaging applications in early-stage clinical diagnosis. Herein, we develop a novel tripartite DNA probe to transport phosphorothioated substrate hairpins and an aptamer for the intramolecular CHA circuit, which achieves detection of a low amount of specific mRNA in living cells and mice.