Details

Autor(en) / Beteiligte

• Hou, Jin
• Du, Yong
• Zhang, Tao
• Mohan, Chandra
• Varghese, Oomman K

Titel

PEGylated (NH)WO nanorod mediated rapid photonecrosis of breast cancer cells

Ist Teil von

• Nanoscale, 2019-05, Vol.11 (21), p.129-1219

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Photothermal therapy has emerged as a potential minimally invasive technique to destroy malignant cells with high selectivity. It utilizes low band gap nanoscale materials as photothermal agents dispersed at the affected area to increase the temperature locally by absorbing radiation in the near infrared (NIR) region and destroys the cells. In an effort to develop a photothermal agent with high efficacy for photothermal therapy, we found that (NH 4 ) x WO 3 nanorods of length 0.5-1.0 μm and diameter ∼100 nm could destroy breast cancer cells rapidly when irradiated with a wavelength in the therapeutic window. The material was prepared using a solvothermal route followed by PEGylation for improving the biocompatibility. X-ray diffraction and transmission electron microscopy studies revealed the hexagonal crystal lattice of the material. The uniform wrapping of polyethylene glycol (PEG) around the nanorods was confirmed using energy dispersive spectroscopy elemental mapping. An 808 nm laser was used to investigate the photothermal responses of the material on SUM-159 and MCF-7 breast cancer cells in vitro . The PEGylated-(NH 4 ) x WO 3 nanorods exhibited rapid temperature elevation from 20 °C to 60 °C within 3 min upon irradiation. A significant growth inhibition of SUM-159 and MCF-7 breast cancer cells with photonecrosis was observed. PEGylated (NH 4 ) x WO 3 nanorods could potentially be used in cancer therapy due to their strong photonecrotic properties at specific NIR wavelengths that suffer from minimal attenuation while passing through biological tissues. Destruction of breast cancer cells by photothermal therapy using (NH 4 ) x WO 3 /PEG nanorods (green - live; red - dead cells).