Details

Autor(en) / Beteiligte

• Ha, Phuong Thu
• Le, Thi Thu Huong
• Bui, Thuc Quang
• Pham, Hong Nam
• Ho, Anh Son
• Nguyen, Linh Toan

Titel

Doxorubicin release by magnetic inductive heating and in vivo hyperthermia-chemotherapy combined cancer treatment of multifunctional magnetic nanoparticles

Ist Teil von

• New journal of chemistry, 2019-04, Vol.43 (14), p.544-5413

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Superparamagnetic iron oxide (Fe 3 O 4 ) nanoparticles have been investigated for decades due to their potential biomedical applications. In this study, we synthesized, characterized and biologically tested multifunctional Fe 3 O 4 -based drug delivery systems for such an application. The nanosystems were successfully prepared with a small size, high saturation magnetization and high drug loading. The Fe 3 O 4 core in an alternating magnetic field could generate enough heat for both effective hyperthermia therapy and doxorubicin release from the alginate shell for chemotherapy. Also, a folate factor was attached to the nanoparticles to help the system to enter and stay in the tumor cells for a longer time. In vivo experiments showed that the combined treatment was very helpful for the survival of lung cancer-bearing mice, especially in the case of the presence of a folate factor. Multifunctional nanosystems help to control drug release and highly improve the cancer treatment efficacy in in vivo models.