Details

Autor(en) / Beteiligte

• Jiang, Jialing
• Tan, Qingwei
• Zhao, Shuxuan
• Song, Heng
• Hu, Liqiang
• Xie, Hexin

Titel

Late-stage difluoromethylation leading to a self-immobilizing fluorogenic probe for the visualization of enzyme activities in live cells

Ist Teil von

• Chemical communications (Cambridge, England), 2019-12, Vol.55 (99), p.15-153

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Reported herein is a novel p -quinone methide-based self-immobilizing fluorogenic probe for the visualization of β-galactosidase activities in live cells. This easily prepared imaging reagent massively increases the fluorescence intensity and covalently links to the activation site with high efficiency upon enzymatic trigger. A novel p -quinone methide-based self-immobilizing and fluorogenic probe is reported for the visualization of β-galactosidase activities in live cells.