Details

Autor(en) / Beteiligte

• Brandt, Marie R
• Vanasschen, Christian
• Ermert, Johannes
• Coenen, Heinz H
• Neumaier, Bernd

Titel

Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity

Ist Teil von

• Dalton transactions : an international journal of inorganic chemistry, 2019-02, Vol.48 (9), p.33-38

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• trans -1,2-Diaminocyclohexane- N , N , N ′, N ′-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55 Mn( ii ) and β + -emitting 52g Mn( ii ) offers access to bimodal Positron Emission Tomography/Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r 1 , a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. 52g Mn. Relaxivity measurements of the 55 Mn-complex showed an enhancement of r 1 of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets. Multimeric trans -1,2-diaminocyclohexane- N , N , N ′, N ′-tetraacetic acid (CDTA) derivatives labelled with a mixture of paramagnetic 55 Mn( ii ) and β + -emitting 52g Mn( ii ) offer the access to bimodal Positron Emission Tomography/Magnetic Resonance (PET/MR) tracers.