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Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity
Ist Teil von
Dalton transactions : an international journal of inorganic chemistry, 2019-02, Vol.48 (9), p.33-38
Erscheinungsjahr
2019
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
trans
-1,2-Diaminocyclohexane-
N
,
N
,
N
′,
N
′-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic
55
Mn(
ii
) and β
+
-emitting
52g
Mn(
ii
) offers access to bimodal Positron Emission Tomography/Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity
r
1
, a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a.
52g
Mn. Relaxivity measurements of the
55
Mn-complex showed an enhancement of
r
1
of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets.
Multimeric
trans
-1,2-diaminocyclohexane-
N
,
N
,
N
′,
N
′-tetraacetic acid (CDTA) derivatives labelled with a mixture of paramagnetic
55
Mn(
ii
) and β
+
-emitting
52g
Mn(
ii
) offer the access to bimodal Positron Emission Tomography/Magnetic Resonance (PET/MR) tracers.
Sprache
Englisch
Identifikatoren
ISSN: 1477-9226
eISSN: 1477-9234
DOI: 10.1039/c8dt04996c
Titel-ID: cdi_rsc_primary_c8dt04996c
Format
–
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