Details

Autor(en) / Beteiligte

• Lakshman, Mahesh K
• Vuram, Prasanna K

Titel

Cross-dehydrogenative coupling and oxidative-amination reactions of ethers and alcohols with aromatics and heteroaromatics

Ist Teil von

• Chemical science (Cambridge), 2017-09, Vol.8 (9), p.5845-5888

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2017

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Cross-dehydrogenative coupling (CDC) is a process in which, typically, a C-C bond is formed at the expense of two C-H bonds, either catalyzed by metals or other organic compounds, or via uncatalyzed processes. In this perspective, we present various modes of C-H bond-activation at sp 3 centers adjacent to ether oxygen atoms, followed by C-C bond formation with aromatic systems as well as with heteroaromatic systems. C-N bond-formation with NH-containing heteroaromatics, leading to hemiaminal ethers, is also an event that can occur analogously to C-C bond formation, but at the expense of C-H and N-H bonds. A large variety of hemiaminal ether-forming reactions have recently appeared in the literature and this perspective also includes this complementary chemistry. In addition, the participation of C-H bonds in alcohols in such processes is also described. Facile access to a wide range of compounds can be attained through these processes, rendering such reactions useful for synthetic applications via C sp 3 bond activations. This is a perspective on cross-dehydrogenative coupling reactions of aromatic and heteroaromatic systems with ethers and alcohols via metal or organic catalysis, and through uncatalyzed means, leading to C-C and C-N bond formation.