Details

Autor(en) / Beteiligte

• Palchykov, Vitalii A
• Chabanenko, Roman M
• Konshin, Valeriy V
• Dotsenko, Victor V
• Krivokolysko, Sergey G
• Chigorina, Elena A
• Horak, Yuriy I
• Lytvyn, Roman Z
• Vakhula, Andriy A
• Obushak, Mykola D
• Mazepa, Alexander V

Titel

Dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide - a versatile building block for the synthesis of new thiopyran-based heterocyclic systemsElectronic supplementary information (ESI) available: Spectral data, in silico screening data. See DOI: 10.1039/c7nj03846a

Erscheinungsjahr

2018-01

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Three series of new cyclic sulfones have been prepared by a one-pot multi-component reaction (MCR) starting from the readily available dihydro-2 H -thiopyran-3(4 H )-one-1,1-dioxide. The in silico screening of the synthesized compounds revealed their high anti-inflammatory, antiarthritic, antiasthmatic and antiallergic potential coupled with the strong probability levels of cystinyl aminopeptidase inhibition. The key structures were confirmed by 2D NMR techniques. Three series of new cyclic sulfones have been prepared by a one-pot multi-component reactions.