Details

Autor(en) / Beteiligte

• Martina, K
• Rotolo, L
• Porcheddu, A
• Delogu, F
• Bysouth, S. R
• Cravotto, G
• Colacino, E

Titel

High throughput mechanochemistry: application to parallel synthesis of benzoxazinesElectronic supplementary information (ESI) available: Experimental procedures and spectral data for compounds 1-14. See DOI: 10.1039/c7cc07758k

Erscheinungsjahr

2018-01

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We describe herein an unprecedented mechanochemical " parallel synthesis " of 3,4-dihydro-2 H -benzo[ e ][1,3]oxazine derivatives via a one pot three component reaction. The new milling system uses a multiposition jar (variable sizes are possible), allowing for the processing of up to 12 samples simultaneously, leading to the formation of a fungicide and a building block for polymer preparation with higher throughput compared to standard milling devices. Mechanochemical "parallel synthesis": processing 12 samples simultaneously allowed fast screening of the optimum reaction conditions and high throughput preparation of benzozaxine derivatives, including a fungicide.