Details

Autor(en) / Beteiligte

• Al Samad, A
• Bethry, A
• Koziolová, E
• Netopilík, M
• Etrych, T
• Bakkour, Y
• Coudane, J
• El Omar, F
• Nottelet, B

Titel

PCL-PEG graft copolymers with tunable amphiphilicity as efficient drug delivery systemsElectronic supplementary information (ESI) available: Scheme S1. Schematic representation of the preparation of the PCL-g-PEG copolymers by a thiol-yne approach. Fig. S1. Excitation spectra of pyrene as a function of the concentration of PCL-g-PEG2k3.2; Fig. S2. Fit curves for the curcumin release from PCL-g-PEG copolymers; Fig. S3. Viability of MCF-7 cells in different media; Fig. S4. Viability of MCF-7 cells

Erscheinungsjahr

2016-09

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The development of flexible drug delivery systems that can be tuned as a function of the drug to be delivered and of the target disease is crucial in modern medicine. For this aim, novel amphiphilic poly( -caprolactone)- g -poly(ethylene glycol) (PCL- g -PEG) copolymers with well-controlled design were synthesized by thiol-yne photochemistry. The grafting density and the copolymer amphiphilicity were easily controlled via the reaction parameters: concentration, reaction time, PEG length and the molar ratio between PCL and PEG or the photoinitiator in the reaction mixture. The self-assembling behavior of the copolymers was studied and a correlation between the composition of PCL- g -PEG and the nanoaggregate diameter sizes (28 to 73 nm) and critical aggregation concentrations (1.1 to 4.3 mg L −1 ) was found. The influence of copolymer amphiphilicity on the drug loading was evaluated with various drugs including anticancer drugs (paclitaxel, ABT-199), drugs to overcome multidrug resistance in cancer cells (curcumin, elacridar), an anti-inflammatory drug (dexamethasone) and an antibacterial drug (clofazimine). Finally, the influence of amphiphilicity on curcumin release and toxicity towards MCF-7 cancer cell lines was studied. The impact of the grafting density, PEG length and the overall EG/CL ratio is discussed in detail. Curcumin loaded PCL- g -PEG with lower EG/CL ratios and shorter PEG chains showed higher toxicity compared to their more hydrophilic counterparts. Efficient drug delivery systems are prepared, thanks to the fine-tuning of the amphiphilicity and architecture of PCL-PEG graft copolymers via a simple photochemical approach.