Details

Autor(en) / Beteiligte

• Yang, Kai-Chuan
• Li, Jun-Long
• Shen, Xu-Dong
• Li, Qiang
• Leng, Hai-Jun
• Huang, Qian
• Zheng, Peng-Kun
• Gou, Xiao-Jun
• Zhi, Yong-Gang

Titel

Facile synthesis of novel spiroheterocycles via diastereoselective aziridination of cyclic enonesElectronic supplementary information (ESI) available: Experimental procedures, characterization data for new compounds and crystallographic data in CIF or other electronic formats. CCDC 1479201. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ra28508b

Erscheinungsjahr

2017-04

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• A collection of novel spiroheterocycles with strained aziridine moieties have been facilely synthesized by using easily accessible starting materials under mild reaction conditions. This procedure is robust, scalable and highly diastereoselective, and also features broad substrate scope. In addition, some of the products show promising in vitro biological activity against a spectrum of pathogens, which might be considered as a clue for the discovery of new antimicrobial agents. A highly diastereoselective aziridination of cyclic enones has been developed under mild conditions, giving an efficient access to a class of novel spiroaziridines which show promising antibacterial activity.