Details

Autor(en) / Beteiligte

• Domarco, O
• Lötsch, D
• Schreiber, J
• Dinhof, C
• Van Schoonhoven, S
• García, M. D
• Peinador, C
• Keppler, B. K
• Berger, W
• Terenzi, A

Titel

Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cellsElectronic supplementary information (ESI) available: Experimental methods, and additional spectroscopic and docking data/pictures. See DOI: 10.1039/c6dt03876j

Erscheinungsjahr

2017-01

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Supramolecular Pt( ii ) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene. Pt( ii ) boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion and influence the expression of G-quadruplex forming genes.