Details

Autor(en) / Beteiligte

• Gates, Zachary P
• Dhayalan, Balamurugan
• Kent, Stephen B. H

Titel

Obviation of hydrogen fluoride in Boc chemistry solid phase peptide synthesis of peptide-αthioestersElectronic supplementary information (ESI) available: LC-MS chromatograms/spectra, and supporting data tables. See DOI: 10.1039/c6cc07891e

Erscheinungsjahr

2016-11

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Under suitable conditions, trifluoromethanesulfonic acid performs comparably to hydrogen fluoride for the on-resin global deprotection of peptides prepared by Boc chemistry solid phase peptide synthesis (SPPS). Obviation of hydrogen fluoride in Boc chemistry SPPS enables the straightforward synthesis of peptide- α thioesters for use in native chemical ligation. Trifluoromethanesulfonic acid performs comparably to hydrogen fluoride for the on-resin global deprotection of peptides prepared by Boc chemistry solid phase peptide synthesis.