Details

Autor(en) / Beteiligte

• Cattaneo, Damiano
• Warrender, Stewart J
• Duncan, Morven J
• Kelsall, Christopher J
• Doherty, Mary K
• Whitfield, Phillip D
• Megson, Ian L
• Morris, Russell E

Titel

Tuning the nitric oxide release from CPO-27 MOFsElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ra24023a

Erscheinungsjahr

2016-02

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Nitric oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that the NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications. Nitric oxide release from CPO-27 MOFs and the resulting coronary artery relaxation response are tuned by isomorphous substitution of Ni into the MOF framework.