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Voltammetric analysis of nitroxoline in tablets and human serum using modified carbon paste electrodes incorporating mesoporous carbon or multiwalled carbon nanotubes
Ist Teil von
RSC advances, 2015-01, Vol.5 (69), p.5686-5697
Erscheinungsjahr
2015
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Mesoporous carbon (MC) was synthesized using a mesoporous SiO
2
template material (SBA-15) and sucrose as the carbon source. SBA-15, MC as well as commercially obtained multi-walled carbon nanotubes (MWCNTs) were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), N
2
sorption isotherms and electrochemical impedance spectra. A carbon paste (CP) electrode modified with either MC or MWCNTs was used as a sensor for sensitive and selective determination of the nitroxoline drug. Using cyclic voltammetry, linear sweep and square-wave adsorptive stripping voltammetry, nitroxoline was found to oxidize
via
one developed peak at MWCNT/CP and MC/CP electrodes compared to unmodified one. This is attributed to the stronger adsorptive character, lower charge transfer resistances and higher electrocatalytic activities of modified CP electrodes than the unmodified CP electrode. A well-defined peak and high current response were observed in a B-R universal buffer (pH 2.5) following preconcentration of nitroxoline by adsorption accumulation at −0.2 V (
vs.
Ag/AgCl/KCl
s
). Limits of detection of 3.0 × 10
−11
, 1.5 × 10
−11
and 3.0 × 10
−12
M nitroxoline, were obtained using the unmodified CP, MWCNT/CP and MC/CP electrodes, respectively. The utility of these sensors was examined for the determination of nitroxoline in its pharmaceutical dosage form (Nibiol® tablets) and human serum.
Mesoporous carbon (MC) was synthesized using mesoporous SiO
2
template material (SBA-15) and sucrose as the carbon source. SBA-15, MC and multi-walled carbon nanotubes (MWCNTs) were used as sensors for determination of nitroxoline drug.