Details

Autor(en) / Beteiligte

• Schmidt, Jens
• Adrian, Juliane
• Christian Stark

Titel

Short and highly efficient synthesis of lipid peroxidation inhibitor pyrrolostatin and some analogues thereofElectronic supplementary information (ESI) available: Full experimental details, analytical data and reproductions of NMR-spectra. See DOI: 10.1039/c5ob01066g

Erscheinungsjahr

2015-07

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A highly efficient and scalable synthesis of potent lipid peroxidation inhibitor pyrrolostatin is reported (4 steps, 48%). In addition to the synthesis of the natural product, strategies for the preparation of analogues differing in the three structural subunits, the polar head group, the N -substituent and the lipophilic tail are described. A highly efficient and scalable synthesis of the potent lipid peroxidation inhibitor pyrrolostatin is presented together with strategies to modify the key structural subunits.