Details

Autor(en) / Beteiligte

• Diedrich, D
• Hamacher, A
• Gertzen, C. G. W
• Alves Avelar, L. A
• Reiss, G. J
• Kurz, T
• Gohlke, H
• Kassack, M. U
• Hansen, F. K

Titel

Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitorsElectronic supplementary information (ESI) available: Experimental details (synthetic protocols, bioassays, X-ray crystallography, computational methods), characterization data of new compounds, and copies of NMR spectra. CCDC 1434499. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5cc10301k

Erscheinungsjahr

2016-02

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A mini library of HDAC inhibitors with peptoid-based cap groups was synthesized using an efficient multicomponent approach. Four compounds were identified as potent HDAC6 inhibitors with a selectivity over other HDAC isoforms. The most potent HDAC6 inhibitor revealed remarkable chemosensitizing properties and completely reverted the cisplatin resistance in Cal27 CisR cells. A mini library of selective HDAC6 inhibitors with peptoid-based cap groups was synthesized using an efficient multicomponent approach.