Details

Autor(en) / Beteiligte

• Rawling, M. J
• Storr, T. E
• Bawazir, W. A
• Cully, S. J
• Lewis, W
• Makki, M. S. I. T
• Strutt, I. R
• Jones, G
• Hamza, D
• Stockman, R. A

Titel

Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone-alkene [3+2] cycloaddition strategyElectronic supplementary information (ESI) available: Experimental procedures, characterisation data, 1H and 13C NMR spectra. CCDC 1045613 and 1045614. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5cc05070g

Erscheinungsjahr

2015-07

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A heterocyclic, sp 3 -rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone-alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced. A heterocyclic, sp 3 -rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone-alkene [3+2] cycloaddition reaction.