Details

Autor(en) / Beteiligte

• Hoenders, Daniel
• Tigges, Thomas
• Walther, Andreas

Titel

Combining the incompatible: Block copolymers consecutively displaying activated esters and amines and their use as protein-repellent surface modifiers with multivalent biorecognitionElectronic supplementary information (ESI) available: Materials, instrumentation, monomer synthesis, synthesis of TEG-NH2 and biotin-TEG-NH2, synthesis of random copolymers, additional data on protein-repellency. See DOI: 10.1039/c4py00928b

Erscheinungsjahr

2014-12

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We present the facile synthesis and orthogonal functionalization of diblock copolymers containing two mutually incompatible segments, i.e. primary amines and activated esters, that are displayed chronologically and synthesized by consecutive radical addition fragmentation transfer polymerization (RAFT) of suitably modified monomers. Post-polymerization modification of the active ester moieties with functionalized triethylene glycol derivatives (TEG-NH 2 /BiotinTEG-NH 2 ) furnishes a protein-repellent block with specific biorecognition, and the activation of the amine groups via deprotection results in newly reactive primary amines. We subsequently use these amines as an anchoring layer for the coating of aldehyde-functionalized polystyrene (PS) colloids and demonstrate tight adhesion and enhanced protein-repellent characteristics combined with specific and multivalent biorecognition of avidin as a function of block ratios. Our strategy demonstrates a viable approach for orthogonal combination of widely needed, but mutually incompatible, functional groups into complex polymer architectures. We present the facile synthesis and orthogonal functionalization of diblock copolymers consisting of two incompatible segments, i.e. primary amines and activated esters, and demonstrate their use as protein-repellent brush layers with multivalent biorecognition.