Details

Autor(en) / Beteiligte

• Wei, Gaofei
• Luan, Weijing
• Wang, Shuai
• Cui, Shanshan
• Li, Fengran
• Liu, Yongxiang
• Liu, Yang
• Cheng, Maosheng

Titel

A library of 1,2,3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluationElectronic supplementary information (ESI) available. See DOI: 10.1039/c4ob01605j

Erscheinungsjahr

2015-01

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A series of novel oleanolic acid coupled 1,2,3-triazole derivatives have been designed and synthesized by employing a Cu( i ) catalyzed Huisgen 1,3-dipolar cycloaddition reaction. The anti-proliferative evaluation indicated that some compounds exhibited excellent anti-cancer activity against the examined cancer cell lines. Among all derivatives, compound 3t possesses the best inhibitory activity against HT1080 cells. A series of pharmacology experiments show that compound 3t significantly induced HT1080 cell apoptosis. Therefore, this compound can serve as a promising lead candidate for further study. A series of novel oleanolic acid coupled 1,2,3-triazole derivatives have been designed and synthesized by employing a Cu( i ) catalyzed Huisgen 1,3-dipolar cycloaddition reaction.