Details

Autor(en) / Beteiligte

• Jung, Danbi
• Maiti, Sukhendu
• Lee, Jae Hong
• Lee, Joung Hae
• Kim, Jong Seung

Titel

Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimagingElectronic supplementary information (ESI) available. See DOI: 10.1039/c3cc49790a

Erscheinungsjahr

2014-02

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis. We developed a target specific thiol probe for rapidly sensing thiols in the cancer cells and cellular imaging.