Details

Autor(en) / Beteiligte

• Kang, Xiaojiao
• Yang, Dongmei
• Dai, Yunlu
• Shang, Mengmeng
• Cheng, Ziyong
• Zhang, Xiao
• Lian, Hongzhou
• Ma, Ping'an
• Lin, Jun

Titel

Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release

Ist Teil von

• Nanoscale, 2013-01, Vol.5 (1), p.253-261

Ort / Verlag

England

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study, multifunctional poly(acrylic acid) modified lanthanide-doped GdVO 4 nanocomposites [PAA@GdVO 4 : Ln 3+ (Ln = Yb/Er, Yb/Ho, Yb/Tm)] were constructed by filling PAA hydrogel into GdVO 4 hollow spheres via photoinduced polymerization. The up-conversion (UC) emission colors (green, red and blue) can be tuned by changing the codopant compositions in the matrices. The composites have potential applications as bio-probes for cell imaging. Meanwhile, the hybrid spheres can act as T 1 contrast agents for magnetic resonance imaging (MRI) owing to the existence of Gd 3+ ions on the surface of composites. Due to the nature of PAA, DOX-loaded PAA@GdVO 4 :Yb 3+ /Er 3+ system exhibits pH-dependent drug releasing kinetics. A lower pH offers a faster drug release rate. Such character makes the loaded DOX easily released at cancer cells. The cell uptake process of drug-loaded composites was observed by using confocal laser scanning microscopy (CLSM). The results indicate the potential application of the multifunctional composites as theragnostics (effective bimodal imaging probes and pH-responsive drug carriers). Multifunctional poly(acrylic acid) modified lanthanide-doped GdVO 4 nanocomposites were fabricated for application as effective bimodal imaging (fluorescent imaging and MRI) probes and pH-responsive drug carriers.