Details

Autor(en) / Beteiligte

• deKrafft, Kathryn E
• Boyle, William S
• Burk, Laurel M
• Zhou, Otto Z
• Lin, Wenbin

Titel

Zr- and Hf-based nanoscale metal-organic frameworks as contrast agents for computed tomographyElectronic supplementary information (ESI) available: Characterization of Hf-UiO, Hf-UiO@SiO2, Hf-UiO@SiO2@PEG, and Hf-NMOF@SiO2@PEG. CT images of Hf-NMOF@SiO2@PEG. See DOI: 10.1039/c2jm32299d

Erscheinungsjahr

2012-08

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Nanoscale metal-organic frameworks (NMOFs) of the UiO-66 structure containing high Zr (37 wt%) and Hf (57 wt%) content were synthesized and characterized, and their potential as contrast agents for X-ray computed tomography (CT) imaging was evaluated. Hf-NMOFs of different sizes were coated with silica and poly(ethylene glycol) (PEG) to enhance biocompatibility, and were used for in vivo CT imaging of mice, showing increased attenuation in the liver and spleen. Hf-based nanoscale metal-organic frameworks were coated with silica and poly(ethylene glycol), and used as contrast agents for computed tomography imaging.