Details

Autor(en) / Beteiligte

• Berardicurti, Onorina
• Navarini, Luca
• Vomero, Marta
• Currado, Damiano
• Biaggi, Alice
• Marino, Annalisa
• Bearzi, Pietro
• Corberi, Erika
• Rigon, Amelia
• Arcarese, Luisa
• Vadacca, Marta
• Mattei, Alessia
• Agrò, Felice Eugenio
• Incalzi, Raffaele Antonelli
• Sambuco, Federica
• Travaglino, Francesco
• Ruscitti, Piero
• Cipriani, Paola
• Giacomelli, Roberto

Titel

The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the “hyperferritinemic syndromes”

Ist Teil von

• Autoimmunity reviews, 2023-05, Vol.22 (5), p.103309, Article 103309

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• A role for COVID19 in “hyperferritinemic syndromes” has been proposed based on its clinical and serological characteristics and its similarities with AOSD. To better understand the molecular pathways responsible of these similarities, we evaluated in the PBMCs of 4 active AOSD patients, 2 COVID19 patients with ARDS, and 2 HCs the expression of genes associated with iron metabolisms, with monocyte/macrophages activation, and finally with NETs formation.