Details

Autor(en) / Beteiligte

• Mirtaleb, Mona Sadat
• Falak, Reza
• Heshmatnia, Jalal
• Bakhshandeh, Behnaz
• Taheri, Ramezan Ali
• Soleimanjahi, Hoorieh
• Zolfaghari Emameh, Reza

Titel

An insight overview on COVID-19 mRNA vaccines: Advantageous, pharmacology, mechanism of action, and prospective considerations

Ist Teil von

• International immunopharmacology, 2023-04, Vol.117, p.109934-109934, Article 109934

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• •The mRNA-based COVID-19 vaccines protected the human through the global immunization.•Immunization follow-ups revealed that these vaccines was effective in eliciting immunity.•In parallel with advantageous of mRNA-based COVID-19 vaccines, some cautions must be considered.•Integration of exogenous mRNA from these vaccines into the host genome is not a common phenomenon.•The mRNA-based COVID-19 vaccines can be scientific patterns for designing other genetic vaccines. The worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has urged scientists to present some novel vaccine platforms during this pandemic to provide a rather prolonged immunity against this respiratory viral infection. In spite of many campaigns formed against the administration of mRNA-based vaccines, those platforms were the most novel types, which helped us meet the global demand by developing protection against COVID-19 and reducing the development of severe forms of this respiratory viral infection. Some societies are worry about the COVID-19 mRNA vaccine administration and the potential risk of genetic integration of inoculated mRNA into the human genome. Although the efficacy and long-term safety of mRNA vaccines have not yet been fully clarified, obviously their application has switched the mortality and morbidity of the COVID-19 pandemic. This study describes the structural features and technologies used in producing of COVID-19 mRNA-based vaccines as the most influential factor in controlling this pandemic and a successful pattern for planning to produce other kind of genetic vaccines against infections or cancers.