Details

Autor(en) / Beteiligte

• Kennedy, Eamonn
• Dennis, Emily L.
• Lindsey, Hannah M.
• deRoon-Cassini, Terri
• Du Plessis, Stefan
• Fani, Negar
• Kaufman, Milissa L.
• Koen, Nastassja
• Larson, Christine L.
• Laskowitz, Sarah
• Lebois, Lauren A. M.
• Morey, Rajendra A.
• Newsome, Mary R.
• Palermo, Cori
• Pastorek, Nicholas J.
• Powers, Abigail
• Scheibel, Randall
• Seedat, Soraya
• Seligowski, Antonia
• Stein, Dan J.
• Stevens, Jennifer
• Sun, Delin
• Thompson, Paul
• Troyanskaya, Maya
• van Rooij, Sanne J. H.
• Watts, Amanda A.
• Tomas, Carissa W.
• Williams, Wright
• Hillary, Frank G.
• Pugh, Mary Jo
• Wilde, Elisabeth A.
• Tate, David F.
• Dennis, Emily L
• Yeates, Keith Owen
• Tate, David F
• Wilde, Elisabeth A

Titel

Harmonizing PTSD Severity Scales Across Instruments and Sites

Ist Teil von

• Neuropsychology, 2023-05, Vol.37 (4), p.398-408

Ort / Verlag

United States: American Psychological Association

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective: The variety of instruments used to assess posttraumatic stress disorder (PTSD) allows for flexibility, but also creates challenges for data synthesis. The objective of this work was to use a multisite mega analysis to derive quantitative recommendations for equating scores across measures of PTSD severity. Method: Empirical Bayes harmonization and linear models were used to describe and mitigate site and covariate effects. Quadratic models for converting scores across PTSD assessments were constructed using bootstrapping and tested on hold out data. Results: We aggregated 17 data sources and compiled an n = 5,634 sample of individuals who were assessed for PTSD symptoms. We confirmed our hypothesis that harmonization and covariate adjustments would significantly improve inference of scores across instruments. Harmonization significantly reduced cross-dataset variance (28%, p < .001), and models for converting scores across instruments were well fit (median R2 = 0.985) with an average root mean squared error of 1.46 on sum scores. Conclusions: These methods allow PTSD symptom severity to be placed on multiple scales and offers interesting empirical perspectives on the role of harmonization in the behavioral sciences. Key Points Question: The precise relationship between scores on different PTSD assessments remains unclear because it is hard to isolate the effects of instrumentation in practice. Findings: We found that individual data sources each come with distinct characteristics and biases that must be addressed before the relationship between different PTSD assessments can be observed and modeled independently. Importance: We propose methods that allow scores on different measures of PTSD symptom severity to compared, which may reduce burden on patients, participants, and researchers. Next Steps: Future work could use these ideas to situate the results of new studies within the larger body of historical literature.