Details

Autor(en) / Beteiligte

• Tolaney, Sara M
• Do, Khanh T
• Eder, Joseph P
• LoRusso, Patricia M
• Weekes, Colin D
• Chandarlapaty, Sarat
• Chang, Ching-Wei
• Chen, Shang-Chiung
• Nazzal, Denise
• Schuth, Eva
• Brunstein, Flavia
• Carrasco-Triguero, Montserrat
• Darbonne, Walter C
• Giltnane, Jennifer M
• Flanagan, William M
• Commerford, S Renee
• Ungewickell, Alexander
• Shapiro, Geoffrey I
• Modi, Shanu

Titel

A Phase I Study of DLYE5953A, an Anti-LY6E Antibody Covalently Linked to Monomethyl Auristatin E, in Patients with Refractory Solid Tumors

Ist Teil von

• Clinical cancer research, 2020-11, Vol.26 (21), p.5588-5597

Ort / Verlag

United States

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• DLYE5953A is an antibody-drug conjugate consisting of an anti-LY6E antibody covalently linked to the cytotoxic agent monomethyl auristatin E. This study characterized the safety, pharmacokinetics, immunogenicity, potential biomarkers, and antitumor activity of DLYE5953A in patients with metastatic solid tumors. This was a phase I, open-label, 3+3 dose-escalation, and dose-expansion study of DLYE5953A administered intravenously every 21 days (Q3W) in patients with locally advanced or metastatic solid malignancies. Sixty-eight patients received DLYE5953A (median, four cycles; range, 1-27). No dose-limiting toxicities were identified during dose escalation (0.2-2.4 mg/kg; = 20). The recommended phase II dose (RP2D) of 2.4 mg/kg Q3W was based on overall safety and tolerability. Dose-expansion cohorts for HER2-negative metastatic breast cancer (HER2-negative MBC; = 23) and non-small cell lung cancer (NSCLC; = 25) patients were enrolled at the RP2D. Among patients receiving DLYE5953A 2.4 mg/kg ( = 55), the most common (≥30%) related adverse events (AEs) included alopecia, fatigue, nausea, and peripheral neuropathy. Grade ≥3 related AEs occurred in 14 of 55 (26%) patients, with neutropenia being the most common (13%). DLYE5953A demonstrated linear total antibody pharmacokinetics at doses of ≥0.8 mg/kg with low unconjugated monomethyl auristatin E levels in blood. Partial response was confirmed in eight of 68 (12%) patients, including three of 29 patients with MBC (10%) and five of 25 patients with NSCLC (20%) at the RP2D. Stable disease was the best response for 37 of 68 (54%) patients. DLYE5953A administered at 2.4 mg/kg has acceptable safety. Preliminary evidence of antitumor activity in patients with HER2-negative MBC and NSCLC supports further investigation of LY6E as a therapeutic target.