Details

Autor(en) / Beteiligte

• Crowley, Andrew R.
• Richardson, Simone I.
• Tuyishime, Marina
• Jennewein, Madeleine
• Bailey, Meredith J.
• Lee, Jiwon
• Alter, Galit
• Ferrari, Guido
• Morris, Lynn
• Ackerman, Margaret E.

Titel

Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses

Ist Teil von

• Immunogenetics (New York), 2023-02, Vol.75 (1), p.1-16

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2023

Quelle

SpringerLink

Beschreibungen/Notizen

• Heritable polymorphisms within the human IgG locus, collectively termed allotypes, have often been linked by statistical associations, but rarely mechanistically, to a wide range of disease states. One potential explanation for these associations is that IgG allotype alters host cell receptors’ affinity for IgG, dampening or enhancing an immune response depending on the nature of the change and the receptors. In this work, a panel of allotypic antibody variants were evaluated using multiplexed, label-free biophysical methods and cell-based functional assays to determine what effect, if any, human IgG polymorphisms have on antibody function. While we observed several differences in FcγR affinity among allotypes, there was little evidence of dramatically altered FcγR-based effector function or antigen recognition activity associated with this aspect of genetic variability.