Details

Autor(en) / Beteiligte

• Yang, Yong
• Wang, Ji‐Jin
• Zhao, Rui‐Zhi
• Huang, Cheng
• Shi, Gui‐Qing
• Zheng, Hao
• Tang, Tian‐Lan
• Liao, Si‐Qin
• Chen, Jin‐Hua
• Shen, Jian‐Zhen
• Liu, Ting‐Bo
• Xu, Ben‐Hua
• Zhang, Yu‐Jing

Titel

The value of routine bone marrow examination in patients with extranodal NK/T‐cell lymphoma staged with PET/CT

Ist Teil von

• Cancer, 2022-11, Vol.128 (22), p.3943-3950

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Limited evidence supports the omission of routine bone marrow (BM) examination (biopsy and aspiration) in patients with nasal‐type extranodal NK/T‐cell lymphoma (ENKTCL). This study was aimed at assessing whether BM examination provides valuable information for positron emission tomography/computed tomography (PET/CT)–based staging in this patient population. Patients and Methods Patients newly diagnosed with ENKTCL who underwent initial staging with both PET/CT and BM examination between 2013 and 2020 were retrospectively identified in two Chinese institutions. Overall, 742 patients were included; the BM examination was positive in 67 patients. Results Compared with BM biopsy alone, the combination of BM biopsy and aspiration assessment did not afford any additional diagnostic value. No patient with a positive BM biopsy was found to have early‐stage disease by PET/CT. BM biopsy or PET/CT led to upstaging from stage III to IV as a result of BM involvement in 21 patients. In 135 patients with distant organ involvement, BM involvement was associated with worse overall survival (OS) and progression‐free survival (PFS) compared with the corresponding durations in patients without BM involvement (2‐year OS: 35.9% vs. 60.4%, p < .001; PFS: 26% vs. 40.7%, p = .003). No difference in survival was noted between groups judged positive based on PET/CT and BM biopsy. Conclusion Compared with aspiration, BM biopsy led to the detection of more BM lesions. Baseline PET/CT can be safely used to exclude BM involvement in early‐stage disease. Overall, routine BM examination affords diagnostic or prognostic value over PET/CT in patients with advanced‐stage nasal‐type ENKTCL. Baseline positron emission tomography/computed tomography (PET/CT) can be safely used to exclude bone marrow (BM) involvement in patients with early‐stage nasal‐type extranodal NK/T‐cell lymphoma (ENKTCL). Compared with PET/CT alone, routine BM examination can afford better diagnostic and prognostic value in advanced‐stage nasal‐type ENKTCL.