The New England journal of medicine, 2022-08, Vol.387 (5), p.397-407
- Wu, Richard L.
- Idris, Azza H.
- Berkowitz, Nina M.
- Happe, Myra
- Gaudinski, Martin R.
- Buettner, Christian
- Strom, Larisa
- Awan, Seemal F.
- Holman, LaSonji A.
- Mendoza, Floreliz
- Gordon, Ingelise J.
- Hu, Zonghui
- Campos Chagas, Andrezza
- Wang, Lawrence T.
- Da Silva Pereira, Lais
- Francica, Joseph R.
- Kisalu, Neville K.
- Flynn, Barbara J.
- Shi, Wei
- Kong, Wing-Pui
- O’Connell, Sarah
- Plummer, Sarah H.
- Beck, Allison
- McDermott, Adrian
- Narpala, Sandeep R.
- Serebryannyy, Leonid
- Castro, Mike
- Silva, Rosa
- Imam, Marjaan
- Pittman, Iris
- Hickman, Somia P.
- McDougal, Andrew J.
- Lukoskie, Ashly E.
- Murphy, Jittawadee R.
- Gall, Jason G.
- Carlton, Kevin
- Morgan, Patricia
- Seo, Ellie
- Stein, Judy A.
- Vazquez, Sandra
- Telscher, Shinyi
- Capparelli, Edmund V.
- Coates, Emily E.
- Mascola, John R.
- Ledgerwood, Julie E.
- Dropulic, Lesia K.
- Seder, Robert A.
2022
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- Autor(en) / Beteiligte
- Wu, Richard L.
- Idris, Azza H.
- Berkowitz, Nina M.
- Happe, Myra
- Gaudinski, Martin R.
- Buettner, Christian
- Strom, Larisa
- Awan, Seemal F.
- Holman, LaSonji A.
- Mendoza, Floreliz
- Gordon, Ingelise J.
- Hu, Zonghui
- Campos Chagas, Andrezza
- Wang, Lawrence T.
- Da Silva Pereira, Lais
- Francica, Joseph R.
- Kisalu, Neville K.
- Flynn, Barbara J.
- Shi, Wei
- Kong, Wing-Pui
- O’Connell, Sarah
- Plummer, Sarah H.
- Beck, Allison
- McDermott, Adrian
- Narpala, Sandeep R.
- Serebryannyy, Leonid
- Castro, Mike
- Silva, Rosa
- Imam, Marjaan
- Pittman, Iris
- Hickman, Somia P.
- McDougal, Andrew J.
- Lukoskie, Ashly E.
- Murphy, Jittawadee R.
- Gall, Jason G.
- Carlton, Kevin
- Morgan, Patricia
- Seo, Ellie
- Stein, Judy A.
- Vazquez, Sandra
- Telscher, Shinyi
- Capparelli, Edmund V.
- Coates, Emily E.
- Mascola, John R.
- Ledgerwood, Julie E.
- Dropulic, Lesia K.
- Seder, Robert A.
- Titel
- Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria
- Ist Teil von
- The New England journal of medicine, 2022-08, Vol.387 (5), p.397-407
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- This phase 1 trial examined an engineered monoclonal antibody, L9LS, targeting the sporozoite. L9LS protected against malaria infection in a human challenge model.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa2203067Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9806693
- Format
- –
- Schlagworte
- Administration, Cutaneous, Administration, Intravenous, Adult, Animals, Antibodies, Monoclonal - administration & dosage, Antibodies, Monoclonal - adverse effects, Antibodies, Monoclonal - pharmacokinetics, Body weight, Child, Child, Preschool, Clinical trials, Disease, Global Health, Health care, Humans, Infections, Infectious Disease, Infectious Disease General, Infectious diseases, Intravenous administration, Malaria, Malaria - prevention & control, Malaria, Falciparum - drug therapy, Malaria, Falciparum - prevention & control, Monoclonal antibodies, Mortality, Mosquitoes, Parasitemia, Parasitemia - parasitology, Parasitic Infections, Pediatrics, Pharmacokinetics, Plasmodium falciparum, Prevention, Proteins, Public Health, Public Health General, Research centers, Safety, Vaccines